CNS Healthcare on new medications for depression: Part 1


STUBBORN DEPRESSION. WELCOME, BOTH, ON “LOOK LOCAL.” SO MANY PEOPLE ARE AFFECTED BY DEPRESSION AND ANXIETY. WHAT ARE THE STATISTICS SHOWING YOU ABOUT DEPRESSION?>>GOSH. IN RECENT ARTICLE THAT I READ, IT’S OVER 16 MILLION PEOPLE WITH DEPRESSION IN THE UNITED STATES AND ALSO THEY IDENTIFIED A GOOD NUMBER OF ADOLESCENTS THAT ARE BUILDING INTO THE NUMBER AS WELL. SO IF YOU THINK ABOUT THAT IN TERMS OF, YOU KNOW, HOW MANY FAMILIES AND EMPLOYERS AND, YOU KNOW, JUST GENERAL DAY-TO-DAY ACTIVITIES THAT ARE IMPACTED BY PEOPLE WHO HAVE DEPRESSION, I MEAN, IT CAN BE PRETTY PROFOUND IN TERMS OF THE EFFECT IT HAS.>>PRETTY SUBSTANTIAL.>>YEAH.>>WE HEARD ABOUT ANTI-DEPRESSION MEDICATIONS THAT ARE OUT THERE, THE SSRI’S, PROZAC, ZOLOFT, PAXIL, THE LIST GOES ON AND ON. THERE ARE ALREADY 20FDA APPROVED BUT THERE ARE SIGNIFICANT ISSUES WITH PEOPLE WHO GET RELIEF FROM THIS MEDICATION. MEDICATION OFTENTIMES TAKES WEEKS TO WORK. EXPLAIN MAYBE THE DISCONNECT THAT PEOPLE MAY HAVE OR WHY IT TAKES SO LONG TO GET INTO YOUR SYSTEM. DOCTOR?>>DEPRESSION IS COMPLICATED AND THE BRAIN IS COMPLICATED. WE HAVE OVER 100 BILLION CELLS IN OUR BRAIN THAT ARE ALL TRYING TO COMMUNICATE WITH EACH OTHER AND THERE’S, YOU KNOW, HUNDREDS OF NEURO TRANSMITTERS THAT SEND CHEMICAL MESSAGES BETWEEN ALL THOSE BRAIN CELLS AND SO FAR, WE’VE JUST KIND OF IDENTIFIED A FEW, KIND OF TWO OR THREE THAT WE FEEL LIKE ARE STRONGLY IMPLICATED IN DEPRESSION BUT FOR THE WAY OUR BODY METABOLIZES THEM AND THE ROLES THEY PLAY IN DEPRESSION, WE’RE STILL LEARNING AND STILL UNDERSTANDING AND THERE’S STILL SO MUCH TO BE EXPLORED.>>WHY DOES IT TAKE SO LONG FOR THE MEDICATION TO WORK? YOU SIGH WEEKS WHEN YOU START TAKING AN SSRI BEFORE WE CAN ACTUALLY START FEELING THE PHYSICAL REMEDY OF IT.>>BECAUSE OF ALL THOSE THINGS HE’S TALKING ABOUT, THOUGH, YOU THINK ABOUT IT CHANGES OVER TIME. YOU KNOW, THE BUILDUP OF THINGS. SO AS THESE MEDICATIONS GET IN, YOU KNOW, THEY START TO NORMALIZE THOSE PATHWAYS AND THINGS ABOUT THAT SO IT TAKES SOME TIME FOR IT TO GET IN THERE AND MAKE THOSE ADJUSTMENTS. WE DON’T KNOW. WE KNOW WHAT IT’S SUPPOSED TO DO AND WHAT IT TARGETS AND BASED ON, YOU KNOW, CLINICAL RESEARCH, TRIALS AND THE THINGS THAT YOU LOOK AT IN TERMS OF IMPROVEMENTS, LIKE YOU MONITOR IMPROVEMENT OVER TIME AND THIS IS KIND OF HOW WE BASE THOSE TIMETABLES.>>OKAY. LET’S TALK ABOUT THE NEW DRUG THAT IS GOING THROUGH CLINICAL TRIALS RIGHT NOW. IT’S CALLEDRAPASONAL. TIME MAGAZINE IN AUGUST, YOU’RE LOOKING AT IT. IT WAS ABOUT A NEW ANTI-DEPRESS ANT, WHAT IT IS STEMMING FROM, THE ROOT MEDICATION AND HOW THIS PARTICULAR MEDICATION IS REALLY A JUMP START. IT REALLY CAN HIT PEOPLE. SO IF YOU — ONCE YOU INGEST THE MEDICATION OR TAKE IT, WHETHER IT’S, YOU KNOW, VIA THE NOSE SPRAY, I THINK I READ THAT THEY’RE DOING IT, OR A SHOT IN THE ARM, PEOPLE ARE GETTING AN IMMEDIATE EFFECT WITHIN 24 HOURS OF DEPRESSION. LET’S TALK ABOUT THAT AND WHAT YOU GUYS ARE DOING IN RELATION TO THAT WITH THIS NEW DRUG YOU HAVE.>>OKAY. SO YEAH, MOST OF — WELL, OF ALL THE ANTI-DEPRESSANTS CURRENTLY ON THE MARKET, THEY TARGET SPECIFIC NEURO TRANSMITTERS RIGHT NOW. DOPAMINE. THIS LOOKS AT A NEW NEURO TRANSMITTER THAT HAS DRAMATIC IMPROVEMENTS IN A VERY SHORT PERIOD OF TIME.>>RIGHT. IT’S LIKE SHOCK TREATMENT ALMOST. PEOPLE CAN GET SUCH A QUICK TURN AROUND EFFECT. YOU’VE ALREADY STARTED THIS. YOU HAVE AN ENROLLMENT PERIOD STILL ONGOING. WHAT IS THE NEW RESEARCH TELLING YOU IN TERMS OF WHAT HAVE YOU BEEN ABLE TO WITNESS?>>WELL, I MEAN, SO FAR THE RESEARCH HAS POINTED THAT PEOPLE CAN HAVE SIGNIFICANT IMPROVEMENT WITHIN 24 HOURS. I THINK THAT’S WHAT IS MOST EXCITING TO US BECAUSE YOU COMPARE THAT TO THE TRADITIONAL TREATMENTS OUT THERE WHICH TAKE FOUR TO SIX WEEKS AND SOME PEOPLE DON’T RESPOND TO THEM AFTER FOUR TO SIX WEEKS TO SEE PEOPLE IMPROVING IN SUCH A SHORT TIME IS EXCITING.>>OKAY. AND, YOU KNOW, A LOT OF PEOPLE ARE ASKING, IS THE DRUG SAFE? WHAT CAN YOU — CAN YOU ADDRESS THAT?>>YEAH. YOU KNOW, THEY HAVE DONE VARIOUS SLIN I CANAL TRIALS SO FAR SO WE’RE NOT — LIKE WE’RE NOT THE STARTING POINT HERE. THERE’S BEEN KIND OF PRECLINICAL TRIALS ALREADY AND IT’S ALREADY PASSING EARLY PHASES OF CLINICAL TRIALS WITH SAFETY DATA. WE HAVE NOT HAD ANY LIKE SIGNIFICANT SIDE EFFECT ISSUES SO FAR WITH WHAT WE’VE SEEN.>>LIKE FOR INSTANCE, THE MEDICATION WE’RE USING IS AN INFUSION. IT’S AN I.V. MEDICATION GIVEN OVER 30 SECONDS. IT’S A VERY SHORT PERIOD OF TIME. SO WE’RE MONITORING PATIENTS BEFORE AND AFTERWARDS AND IN TERMS O TOLARABILITY, IT’S NOT TESTED. AND SO THIS MEDICATION, WHILE IT’S NOT THAT, IT TENDS TO THE SAME AREA OF THE BRAIN AND THE SAME TYPE O CHEMICALS, WITH KATAMINE THERE’S SOME PSYCHOSIS, EVEN DEPENDENCE IN MANY SITUATIONS. BUT, YOU KNOW, THIS ONE IS KIND OF LIKE THE CLEANER VERSION.>>SIDE EFFECTS HAVE BEEN REMOVED.>>IT’S DIFFERENT WITHOUT THOSE WORRIES. AND SO FAR, TORELABILITY IS GREAT.>>IT’S AN INFUSION DRUG. IF YOU COME TO CNS HEALTH CARE, WHERE THEY MONITOR YOU, I WANT PEOPLE TO UNDERSTAND. IT’S AN INFUSION SO THEREFORE, IS IT A SHOT? IS IT SOME KIN OF — HOW WOULD YOU — GIVE AN I.V.?>>YES OVER 30 SECONDS.>>AT ONE POINT, IT’S NOT PAINFUL.>>OKAY. WHEN WE COME BACK, WE’LL TALK MORE ABOUT THE RESULTS THAT THEY’RE SEEING, MORE ABOUT T SPECIFICS ON THIS MEDICATION. WE’LL BE BACK IN A MOMENT TO DISCUSS THAT. BUT FIRST, A LOCAL BUSINESS IS TEAMING UP WITH THE SOCCER CENTER TO HELP THOSE IN NEED. REALTY EXECUTIVE OCEANSIDE WILL BE THE DROPOFF FOR ALL NON PERISHABLE FOOD ITEMS FOR THE MONTH OF SEPTEMBER. REAL ESTATE BROKER IS STEPPING UP TO GIVE BACK TO THE COMMUNITY AND THOSE IN NEED FOR JACKSONVILLE. YOU CAN DROP OFF YOUR NON PERISHABLE ITEMS AT REALTY EXECUTIVES OCEANSIDE. THAT’S LOCATED AT THE CORNER OF KERNAN AND BEACH BOULEVARDS AT THE KERNAN SQUARE SHOPPING CENTER. YOU CAN MAKE THE DROPOFF BETWEEN

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