Standard vs. High Dose Ketamine Infusions for Treatment-Resistant Depression

There was a recent article published in Molecular
Psychiatry in 2018. They took varying dosages of ketamine in the
treatment of depression, and they did either 0.1 mg/kg, 0.2 mg/kg, 0.5 mg/kg, or 1.0 mg/kg
dosages. As well as an active placebo of 0.045* mg/kg
of midazolam. And what they found was that the 0.5 and the
1.0 mg/kg doses had the most pronounced effects in reducing the symptoms of depression on
the Hamilton Depression Rating Score. So at Reset Ketamine, we like to go for higher
doses of ketamine, because actually believe that the higher the dose, the more likely
that the patient will have a non-ordinary state of consciousness. Which, other studies have shown that the more
these mystical or spiritual effects that these patients receive, the more pronounced and
prolonged the effect of the ketamine infusion will be. So, the best doses of ketamine are, in this
study, either 0.5 mg/kg or 1.0 mg/kg. And we agree with this: That when we see our
patients, we go for ascending doses of ketamine to achieve the maximal effect possible. What are your thoughts on this? Do you have any questions or comments? Please, leave them below.

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  1. What does it normally “feel like” to receive Ketamine treatment? Obviously since it is administered in a clinical setting I’m not looking to abuse anything. MDD w/ Anxiety. Rated at 70% by the VA. I’ve tried celexa, Wellbutrin, sertraline, and another that escapes me at the moment. I’ve never felt any different. I just started looking at this but I’ve never used any hallucinogens (clinically or recreationally) and I’m worried that it may be too much. Any info is appreciated.

  2. I agree with you from the perspective of an educated patient. The stronger the out of body experience the more positive effects are achieved. However, the higher doses can be scary for some patients. You should always go into any treatments that involve hallucinations with as open a mind as possible and remember “you’re okay”. Ketamine if used properly is the best treatment I have had, I do not recommend trying by yourself, all introverts or Veterans with extreme avoidance should still go through a medical clinic under a doctors supervision.

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