The changing face of migraine


Migraine affects 12% of the global
population, including children. Although the severity of symptoms varies among
the nearly 1 billion people who suffer from the disorder, migraine ranks as the
most disabling disease in people under 50. Fortunately, a promising new class of
drugs for the treatment of migraine is on the horizon: monoclonal antibodies
against calcitonin gene-related peptide or its receptor. Researchers are also
gaining ground on the genetic origins of migraine – and therefore biomarkers for
targeted precision therapy. As such, personalized care practices are
becoming more commonplace. Much work however, remains to be done. A special
collection of review articles on migraine, published in The Journal of
Headache and Pain in collaboration with Springer Healthcare Independent Medical
Education, explores the changing face of migraine and examines where researchers
are today in meeting the long-standing unmet need for individualized and
targeted approaches. In this themed series, Paolo Martelletti, Messoud Ashina and Lars Edvinsson introduce a comprehensive body of work
that explores the genetics of migraine. A review, for example, covers the advances
in understanding the genes and genetic variations implicated in migraine
etiology. That and similar work naturally raised questions about targeted therapy, many of which are addressed by researchers. The team discusses recent data on promising anti-migraine therapies on the horizon. Meanwhile, there
is research examining the prospects of polytherapies that tag-team the
treatment of migraine and common comorbidities. Of course, at the core of
any treatment is the patient and his or her quality of life. In this vein, a nuanced perspective looks at the impact of migraine on work life and everyday
activities, as told by those who suffer from migraine disorders themselves. This
collaborative article series represents the frontier of today’s migraine
research – surveyed by some of the world’s leading experts. The collective knowledge
gathered here serves as a guide for those navigating through the complexities of migraine disorders in the clinic and beyond. To read the full
selection of articles, visit the journal website. Click on the link below.

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